6533b829fe1ef96bd128a4ff
RESEARCH PRODUCT
Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.
Astrid GnekowClaudia ParetHelmut HanenbergClaudia SpixDieter KörholzRoland KapplerUwe KordesMichaela KuhlenMarkus MetzlerKornelius KerlPeter VorwerkInes B. BrechtInes B. BrechtMartin StanullaMareike RascheThorsten SimonGudrun GoehringBirgit BurkhardtMartin SchrappeIvo LeuschnerNorbert GrafReinhard SchneppenheimTim RippergerDietmar R. LohmannUdo KontnyEwa KoscielniakStefan S. BielackKatja Von HoffKristian W. PajtlerKristian W. PajtlerOlaf RießMartin ZenkerDietrich Von SchweinitzChristian P. KratzWilly WössmannKathrin ThomayDominik SchneiderChristof M. KrammMonika Sparber-sauerMiriam ErlacherJulia HauerLüder Hinrich MeyerMichael C. FrühwaldUta DirksenPeter KaatschDoris SteinemannBritta LamottkeAlexandra RussoGudrun FleischhackChristopher SchroederMarcin W. WlodarskiOlga MoserSimone HettmerBarbara HeroDirk ReinhardtRainer NustedeArndt BorkhardtThomas KlingebielAndreas E. KulozikOlaf WittPetra TemmingStefan M. PfisterStefan M. PfisterKlaus-michael DebatinJuliane HoyerBrigitte SchlegelbergerAngelika EggertStefanie ZimmermannStefan RutkowskiCornelia EckertMartin A. HorstmannCharlotte M. NiemeyerHedwig E. DeubzerAndrea MeinhardtAndré O. Von BuerenBrigitte StrahmGabriele CalaminusThomas IlligMichaela Nathrathsubject
0301 basic medicineHistoryMedizinGene Expression0302 clinical medicineNeoplasm Proteins/geneticsNeoplasmsChildGenetics (clinical)Societies Medicalddc:618HematologyJuvenile myelomonocytic leukemiaCancer predispositionSyndromeFocus Groups21st Century3. Good healthNeoplasm Proteins030220 oncology & carcinogenesisHematologic NeoplasmsGenetic Testing/methodsmedicine.medical_specialtyAdolescentGenetics MedicalGenetic CounselingHistory 21st CenturyMedical/history/instrumentation/methodsFamilial adenomatous polyposis03 medical and health sciencesInternal medicineGeneticsmedicineHumansFocus Groups/methodsGenetic Predisposition to DiseaseGenetic TestingIntensive care medicineGenetic Counseling/ethicsbusiness.industryHematologic Neoplasms/diagnosis/genetics/pathologyCancermedicine.diseasePediatric cancerHuman genetics030104 developmental biologyLi–Fraumeni syndromeNeoplasms/diagnosis/genetics/pathologyMutationMedical/historySocietiesbusinessdescription
Heritable predisposition is an important cause of cancer in children and adolescents. Although a large number of cancer predisposition genes and their associated syndromes and malignancies have already been described, it appears likely that there are more pediatric cancer patients in whom heritable cancer predisposition syndromes have yet to be recognized. In a consensus meeting in the beginning of 2016, we convened experts in Human Genetics and Pediatric Hematology/Oncology to review the available data, to categorize the large amount of information, and to develop recommendations regarding when a cancer predisposition syndrome should be suspected in a young oncology patient. This review summarizes the current knowledge of cancer predisposition syndromes in pediatric oncology and provides essential information on clinical situations in which a childhood cancer predisposition syndrome should be suspected.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 | American journal of medical genetics. Part A |