Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population.

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RESEARCH PRODUCT

Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population.

Fernando Verdú Ana Castelló Francesc Francés Jose Antonio Costa Olga Portolés

subject

Drug Adult Male Adolescent Alcohol Drinking Genotype Substance-Related Disorders media_common.quotation_subject Receptors Opioid mu Alcohol Drug abuse chemistry.chemical_compound Tobacco Use Young Adult Sex Factors Gene Frequency Polymorphism (computer science)Surveys and Questionnaires Tobacco Genetic variation medicine Humans Association (psychology)media_common Aged Genetics Aged 80 and over lcsh:R5-920 Genetic polymorphism Polymorphism Genetic business.industry Addiction Middle Aged medicine.disease Substance abuse Phenotype chemistry Haplotypes Sample size determination Spain Case-Control Studies Female Gene-Environment Interaction Alcohol lcsh:Medicine (General)business Demography Research Article

description

Evidence gained from animals and humans suggests that the encephalic opioid system might be involved in the development of drug addiction through its role in reward. Our aim is to assess the influence of genetic variations in the opioid receptor mu 1 on alcohol and tobacco consumption in a Spanish population. 763 unrelated individuals (465 women, 298 men) aged 18-85 years were recruited between October 2011 and April 2012. Participants were requested to answer a 35-item questionnaire on tobacco and alcohol consumption, as well as to complete the AUDIT and Fagerström tests. Individuals were genotyped for three polymorphisms in the opioid receptor mu 1 (OPRM1) gene, using a TaqMan® protocol. In males, the rs10485057 polymorphism was associated with total pure ethanol intake and with the risk of being an alcohol consumer. Also, this polymorphism was significantly associated with higher Fagerström scores. Rs1799971 had a different influence on adaptive and maladaptive patterns of alcohol use. Despite the limited sample size, our study might enrich current knowledge on patterns of alcohol use, because it encompasses both extreme and adaptive phenotypes, providing thus a wider perspective on this subject.

year	journal	country	edition	language
2015-04-25	Bosnian journal of basic medical sciences

10.17305/bjbms.2015.243 https://pubmed.ncbi.nlm.nih.gov/26042510