6533b829fe1ef96bd128ab70

RESEARCH PRODUCT

Temporal Profile of Gene Induction After Venous Ischemia and Effects of Spreading Depression

T. NishiokaTakanobu KaidoD. BartschY. KamadaAxel HeimannC. HeersOliver Kempski

subject

medicine.medical_specialtybiologybusiness.industryPenumbraIschemiaGene inductionmedicine.diseaseVein occlusionCortical spreading depressionInternal medicineAnesthesiaOcclusionGene expressioncardiovascular systemCardiologybiology.proteinMedicinebusinessCaspase

description

Occlusion of two adjacent cortical veins is followed by a widespread reduction of rCBF and the occurrence of small infarcts, which become larger if spreading depression (SD) occurs. The infarct matures over time with TUNEL-positive cells seen in the penumbra up to 4 days after vein occlusion. Caspase inhibition with zVAD.fmk reduces infarct size. Here, the time course of gene expression in the penumbra is compared to that induced by SD alone.

yearjournalcountryeditionlanguage
2004-01-01
https://doi.org/10.1007/978-3-642-18713-1_3