6533b829fe1ef96bd128abd1
RESEARCH PRODUCT
Antimykotische Wirkstoffe, 20. Mitt.: Bioisostere 6-Arylpyrimidin-Derivate
Alfred KreutzbergerAngelika Burgersubject
In vivoChemistryStereochemistryDrug DiscoveryPharmaceutical Sciencedescription
Durch Kondensation von N-(2-Hydroxyethyl)-N-methylguanidinsulfat (1) mit den 1-Aryl-substituierten β-Diketonen 4a-e erhalt man die bioisosteren 2-[(2-Hydroxyethyl)-methylamino]-6-arylpyrimidine 5a-e. Die Verbindungen 5a-c besitzen signifikante antimykotische in vitro- und in vivo-Aktivitaten. Antimycotic Agents, XX Bioisosteric 6-Arylpyrimidine Derivatives Condensation of N-(2-hydroxyethyl)-N-methylguanidine-sulfate (1) with the β-diketones 4a-e bearing 1-aryl substituents leads to the bioisosteric 2-[(2-hydroxyethyl)-methylamino]-6-arylpyrimidines 5a-e. Compounds 5a-c exhibit significant antimycotic in vivo and in vitro activities.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-01-01 | Archiv der Pharmazie |