6533b829fe1ef96bd128ac47
RESEARCH PRODUCT
Addition reactions of heterocycles—IV
Michele RucciaN. VivonaGiuseppe CusmanoFranco PiozziMaria Luisa Marinosubject
Indole testAddition reactionChemistryOrganic ChemistryDrug DiscoveryOrganic chemistryChemical dataReactivity (chemistry)Ring (chemistry)BiochemistryMedicinal chemistryCycloadditiondescription
Abstract The reactivity of indole derivatives towards nitrilimines has been studied. Substituents at positions 1, 2 and 3 of the indole ring greatly affect the course of the reaction. 1,3-Dipolar cycloaddition products (3a,8a,dihydropyrazole-[3,4-b]-indole derivatives) and non-cyclic addition products (3-indolyl derivatives) were obtained depending on these substituents. The structures reported were assigned on the basis of satisfactory analytical, spectroscopic and chemical data.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1973-01-01 | Tetrahedron |