6533b829fe1ef96bd128ad71
RESEARCH PRODUCT
Cardiovascular control and time domain granger causality: Insights from selective autonomic blockade
Marco Di RienzoTito BassaniPaolo CastiglioniVlasta BaripLuc QuintinGiandomenico NolloAndrei CividjanAlberto PortaLuca Faessubject
AdultMaleGeneral MathematicsGeneral Physics and AstronomyBlood PressurePropranololPharmacologyBaroreflexArterial pressure variability; Autonomic nervous system; Baroreflex; Cardiovascular control; Granger causality; Heart rate variability; Mathematics (all); Engineering (all); Physics and Astronomy (all)Models BiologicalPhysics and Astronomy (all)Engineering (all)Respiratory RateGranger causalityBiological ClocksHeart RateMuscarinic acetylcholine receptormedicineHumansHeart rate variabilityAutonomic nervous systemMathematics (all)Computer SimulationHeart rate variabilityFeedback PhysiologicalChemistryGeneral EngineeringMiddle AgedBaroreflexClonidineAtropineAutonomic nervous systemCardiovascular controlSettore ING-INF/06 - Bioingegneria Elettronica E InformaticaGranger causalityFemaleArterial pressure variabilityAutonomic Nerve Blockmedicine.drugdescription
We studied causal relations among heart period (HP), systolic arterial pressure (SAP) and respiration (R) according to the definition of Granger causality in the time domain. Autonomic pharmacological challenges were used to alter the complexity of cardiovascular control. Atropine (AT), propranolol and clonidine (CL) were administered to block muscarinic receptors, β-adrenergic receptors and centrally sympathetic outflow, respectively. We found that: (i) at baseline, HP and SAP interacted in a closed loop with a dominant causal direction from HP to SAP; (ii) pharmacological blockades did not alter the bidirectional closed-loop interactions between HP and SAP, but AT reduced the dominance of the causal direction from HP to SAP; (iii) at baseline, bidirectional interactions between HP and R were frequently found; (iv) the closed-loop relation between HP and R was unmodified by the administration of drugs; (v) at baseline, unidirectional interactions from R to SAP were often found; and (vi) while AT induced frequently an uncoupling between R and SAP, CL favoured bidirectional interactions. These results prove that time domain measures of Granger causality can contribute to the description of cardiovascular control by suggesting the temporal direction of the interactions and by separating different causality schemes (e.g. closed loop versus unidirectional relations).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-01 |