New alkaloid antibiotics that target the DNA topoisomerase I of Streptococcus pneumoniae

6533b829fe1ef96bd128ae7a

RESEARCH PRODUCT

New alkaloid antibiotics that target the DNA topoisomerase I of Streptococcus pneumoniae

Adela G. De La Campa María Teresa García Maria-jesus Sanz Noella Silva-martin Juan A. Hermoso María Amparo Blázquez María José Ferrándiz

subject

Models Molecular Topoisomerase-I Inhibitor medicine.disease_cause Microbiology Biochemistry Cell Line Microbiology 03 medical and health sciences chemistry.chemical_compound Alkaloids Bacterial Proteins Streptococcus pneumoniae medicine Humans Aporphine Molecular Biology Escherichia coli 030304 developmental biology chemistry.chemical_classification 0303 health sciences Dose-Response Relationship Drug biology 030306 microbiology Topoisomerase Cell Biology Phenanthrenes Protein Structure Tertiary Anti-Bacterial Agents 3. Good health Streptococcus pneumoniae Enzyme DNA Topoisomerases Type I chemistry Biochemistry biology.protein DNA supercoil Topoisomerase I Inhibitors Growth inhibition

description

16 pags, 3 figs, 3 tabs

year	journal	country	edition	language
2011-01-01	Journal of Biological Chemistry 286: 6402-6413 (2011)

10.1074/jbc.m110.148148 http://hdl.handle.net/10261/245546

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