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RESEARCH PRODUCT
Reanalysis of Chinese Treponema pallidum samples: all Chinese samples cluster with SS14-like group of syphilis-causing treponemes
Lenka MikalováDavid ŠMajsMichal StrouhalKay NieseltJan OppeltJan OppeltNatasha AroraFernando González-candelassubject
0301 basic medicineChinaLineage (genetic)Sequencing datalcsh:MedicineGenome sequencingPolymorphism Single NucleotideGeneral Biochemistry Genetics and Molecular BiologyDNA sequencing03 medical and health sciencesmedicineHumansTreponema pallidumSyphilislcsh:Science (General)lcsh:QH301-705.5GenePhylogenyGeneticsTreponemaPhylogenetic analysisbiologyPhylogenetic treeintegumentary systemlcsh:RGeneral MedicineSequence Analysis DNAbiology.organism_classificationmedicine.disease3. Good healthSingle nucleotide variantResearch Note030104 developmental biologylcsh:Biology (General)SyphilisMixed patternGenome Bacteriallcsh:Q1-390description
[Objective]: Treponema pallidum subsp. pallidum (TPA) is the causative agent of syphilis. Genetic analyses of TPA reference strains and human clinical isolates have revealed two genetically distinct groups of syphilis-causing treponemes, called Nichols-like and SS14-like groups. So far, no genetic intermediates, i.e. strains containing a mixed pattern of Nichols-like and SS14-like genomic sequences, have been identifed. Recently, Sun et al. (Oncotarget 2016. https://doi. org/10.18632/oncotarget.10154) described a new “phylogenetic group” (called Lineage 2) among Chinese TPA strains. This lineage exhibited a “mosaic genomic structure” of Nichols-like and SS14-like lineages.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-11 | BMC Research Notes |