6533b829fe1ef96bd128b01e
RESEARCH PRODUCT
Pavlovian conditioning of corticotropin-releasing factor-induced increase of blood pressure and corticosterone secretion in the rat
M. KreutzU. KrauseRobert MurisonVetter HHendrik LehnertDirk H. Hellhammersubject
Malemedicine.medical_specialtySympathetic Nervous SystemBaroreceptorCorticotropin-Releasing HormonePhysiologyConditioning ClassicalPituitary-Adrenal SystemHemodynamicsBlood Pressurechemistry.chemical_compoundStress PhysiologicalCorticosteroneInternal medicineHeart ratemedicineAnimalsEndocrine systemInjections Intraventricularbusiness.industryClassical conditioningRats Inbred StrainsRatsAutonomic nervous systemEndocrinologyBlood pressurechemistryCorticosteronebusinesshormones hormone substitutes and hormone antagonistsdescription
Corticotropin-releasing factor (CRF) is clearly involved in the central regulation of the pituitary-adrenal axis and, moreover, of autonomic nervous system functions. Enhanced sympathetic activity with subsequent increases in blood pressure and heart rate and attenuation of the baroreceptor reflex results from the intracerebroventricular (i.c.v.) administration of CRF. Additionally, the peptide has a variety of potent effects on behavioural responses in animals similar to those observed after an experimentally evoked stress. It was therefore of obvious interest to examine whether CRF is a possible mediator of the learning processes associated with physiological stress reaction patterns. This report clearly demonstrates a classical conditioning of the endocrine (i.e. corticosterone secretion) and haemodynamic (i.e. blood pressure) sequelae following central CRF application and thus indicates that this mechanism is of physiological significance for learned stress responses.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-05-01 | Acta Physiologica Scandinavica |