6533b829fe1ef96bd128b032
RESEARCH PRODUCT
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
Thomas J. WangThomas J. WangAndré G. UitterlindenAravinda ChakravartiKathryn L. LunettaKathryn L. LunettaChristopher Newton-chehChristopher Newton-chehGeorg EhretNicholas L. SmithNicholas L. SmithStefan KääbJerome I. RotterThomas MeitingerVilmundur GudnasonEmelia J. BenjaminEmelia J. BenjaminPhilip A. WolfPhilip A. WolfElsayed Z. SolimanGerhard SteinbeckKenneth RiceEric BoerwinkleRenate B. SchnabelRenate B. SchnabelRalph B. D'agostinoRalph B. D'agostinoTamara B. HarrisH.-erich WichmannBruno H. StrickerDan E. ArkingPatrick T. EllinorJacqueline C.m. WittemanMartin G. LarsonMartin G. LarsonBruce M. PsatyBruce M. PsatyNona SotoodehniaAlvaro AlonsoSunil K. AgarwalAnna KöttgenSusan R. HeckbertSusan R. HeckbertAlbert HofmanMan LiJoshua C. BisKristin D. MarcianteMoritz F. SinnerSiegfried PerzCornelia M. Van DuijnFernando RivadeneiraGudny EiriksdottirThomas LumleyCharlotte Van NoordArne PfeuferAlanna M. ChamberlainMartina MuellerDaniel LevyDaniel LevyW. H. Linda KaoLenore J. LaunerJan HeeringaThor AspelundAlbert V. SmithSteven A. LubitzRamachandran S. VasanAbbas DehghanKe Wangsubject
single nucleotideEuropean Continental Ancestry Group/*geneticsmedicine.medical_specialtyMutation/*geneticsGenome-wide association study030204 cardiovascular system & hematologyBiologyPolymorphism Single NucleotideArticleWhite PeoplepolymorphismHomeodomain Proteins/*genetics03 medical and health sciences0302 clinical medicineMeta-Analysis as TopicInternal medicineAtrial FibrillationGeneticsmedicineHumansGenetic Predisposition to Disease030304 developmental biologyGenetic associationHomeodomain Proteinsddc:6160303 health sciencesAtrial Fibrillation/*geneticsReproducibility of ResultsAtrial fibrillationOdds ratioPolymorphism Single Nucleotide/geneticsmedicine.disease*Genetic Predisposition to DiseaseMeta-analysisRelative riskMutationCohortepidemiologyChromosomes Human Pair 16/geneticsChromosomes Human Pair 16Genome-Wide Association Studydescription
We conducted meta-analyses of genome-wide association studies (GWAS) for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a novel locus for AF (ZFHX3, rs2106261, risk ratio [RR]=1.19; P=2.3×10−7), an association that was replicated in the German AF Network (odds ratio=1.44; P=1.6×10−11). Combining the discovery and replication results, rs2106261 was significantly associated with AF (RR=1.25; P=1.8×10−15).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-01-01 | Nature Genetics |