6533b82afe1ef96bd128b67b
RESEARCH PRODUCT
A two-step synthesis of new macrobicyclic aza-ligands starting from “trans”dioxocyclam as diprotected macrocycle
Stéphane BrandèsFranck DenatRoger GuilardSylvie Lacoursubject
chemistry.chemical_classificationChemistryOrganic ChemistryDrug DiscoveryTwo stepSurface modificationAmine gas treatingPolymerDioxocyclamCross linkerGraftingBiochemistryCombinatorial chemistrydescription
Abstract A rapid and convenient synthesis of two small aza-cryptands containing a 1,4,8,11-tetraazacyclotetradecane backbone is reported. This strategy can be applied to the preparation of many other aza-cages by varying the nature of the cross linker. Moreover, the two remaining secondary amine sites may allow the functionalization of these ligands or their grafting on a polymer.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-06-01 | Tetrahedron Letters |