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RESEARCH PRODUCT

Spontaneous Cortical Spreading Depression and Intracranial Pressure Following Acute Subdural Hematoma in a Rat

Oliver KempskiJ. Stephan TretzelAxel HeimannBeat Alessandri

subject

Mean arterial pressurebusiness.industryTraumatic brain injuryCortical spreading depressionAnesthesiaIschemiaMedicineSubdural hemorrhageBlood volumebusinessmedicine.diseaseAcute subdural hematomaIntracranial pressure

description

Acute subdural hemorrhage (ASDH) is a frequent and devastating consequence of traumatic brain injury. Tissue damage develops rapidly and makes treatment even more difficult. Management of increased intracranial pressure (ICP) due to extravasated blood volume and brain swelling is often insufficient to control all adverse effects of ASDH. In addition to sheer volume, spontaneously triggered cortical spreading depression (CSD) that leads to cell death following ischemia or trauma may contribute to injury development after ASDH. Therefore, we explored the occurrence of CSD by tissue impedance (IMP) measurement in a rat model subjected to ASDH. IMP and intraventricular and mean arterial pressure were monitored before (baseline), during (blood infusion), and after ASDH for 3 h.

yearjournalcountryeditionlanguage
2012-01-01
https://doi.org/10.1007/978-3-7091-0956-4_72