6533b82afe1ef96bd128b731
RESEARCH PRODUCT
Mesenchymal Stromal Cells From Wharton's Jelly (WJ-MSCs)
Giampiero La RoccaAldo GerbinoPeter KruzliakRadka OpatrilovaRita Anzalonesubject
0301 basic medicineStromal cellMesenchymal stem cellBiologyUmbilical cordRegenerative medicineCell biologyCell therapy03 medical and health sciences030104 developmental biology0302 clinical medicinemedicine.anatomical_structurePlacentaWharton's jellyMucous Connective Tissuemedicine030217 neurology & neurosurgerydescription
Abstract Among the potential sources of cells with attractive features for regenerative medicine, perinatal tissues have gained much attention in recent years. The umbilical cord (UC) is a fundamental part of placenta, the organ providing feto–maternal interface during pregnancy. The mature UC is constituted by three vessels, one vein, and two arteries, which are comprised into a meshwork formed by a mature mucous connective tissue, named Wharton's jelly (WJ). Recent data from research groups worldwide highlighted that WJ stromal cells possess unique features both in terms of differentiative ability and immunomodulation. These features are desirable for cellular therapy applications, thereby expanding the number of possible clinical uses of these cells. In this chapter, we provide insights on the developmental history of WJ cells and the recent developments for their use in both “replacement type” or “supportive” regenerative medicine applications in key diseases.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 |