6533b82afe1ef96bd128b772

RESEARCH PRODUCT

Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging

Cristina MorsianiLiana SpazzafumoYousin SuhHwa Jin JungFabiola OlivieriMassimiliano BonafèJose ViñaMiriam Capri

subject

0301 basic medicineCirculating mirnasAgingOffspringmedia_common.quotation_subjectBiologyBioinformaticsArticleExtracellular Vesicles03 medical and health sciencesCirculating microRNAmicroRNAEpigenetic ProfileAnimalsHumansCentenarianmedia_commonInflammationPerspective (graphical)LongevityPhenotype3. Good healthMicroRNAsCirculating MicroRNA030104 developmental biologyAging trajectorieOffspring of centenariansmiR-21-5pBiomarkersDevelopmental Biology

description

Human aging is a lifelong process characterized by a continuous trade-off between pro-and anti-inflammatory responses, where the best-adapted and/or remodeled genetic/epigenetic profile may develop a longevity phenotype. Centenarians and their offspring represent such a phenotype and their comparison to patients with age-related diseases (ARDs) is expected to maximize the chance to unravel the genetic makeup that better associates with healthy aging trajectories. Seemingly, such comparison is expected to allow the discovery of new biomarkers of longevity together with risk factor for the most common ARDs. MicroRNAs (miRNAs) and their shuttles (extracellular vesicles in particular) are currently conceived as those endowed with the strongest ability to provide information about the trajectories of healthy and unhealthy aging. We review the available data on miRNAs in aging and underpin the evidence suggesting that circulating miRNAs (and cognate shuttles), especially those involved in the regulation of inflammation (inflamma-miRs) may constitute biomarkers capable of reliably depicting healthy and unhealthy aging trajectories.

yearjournalcountryeditionlanguage
2017-07-01
10.1016/j.mad.2016.12.004http://hdl.handle.net/11585/674685