6533b82afe1ef96bd128b8e0

RESEARCH PRODUCT

Midventricular dyskinesia during clozapine treatment?

A RotoloGiovanni FazioGiuseppe CoppolaS AugugliaroFarinella MAssennato PasqualeGianfranco CiaramitaroNovo GiuseppinaSalvatore Novo

subject

Malemedicine.medical_specialtyMyocarditisPericardial effusionPericardial EffusionVentricular Function LeftYoung AdultInternal medicineVentricular DysfunctionmedicineSegmental wall motionHumanscardiovascular diseasesYoung adultClozapineMidventricular dyskinesiaClozapineUltrasonographyHeart Failurebusiness.industryGeneral Medicinemedicine.diseaseMyocardial ContractionMyocarditisDyskinesiaSchizophreniaHeart failureAcute DiseaseSchizophreniaVentricular Function Rightcardiovascular systemCardiologymedicine.symptomCardiology and Cardiovascular MedicinebusinessAntipsychotic Agentsmedicine.drug

description

This is the case of a young man suffering from schizophrenia and treated with clozapine. He developed acute heart failure associated with pericardial effusion and midventricular dyskinesia with severe systolic dysfunction and left ventricular dilatation at echocardiogram, readily resolved after the suspension of clozapine therapy. The segmental wall motion abnormalities observed at echocardiogram in this case are peculiar and have never been described before. The possible cardiotoxic effects of clozapine have been reported previously in the literature. Because of its serious potential side effects this drug is not considered the first choice for treatment of schizophrenia. Before beginning treatment, patients should undergo a cardiac evaluation, and they should also be periodically followed up with echocardiograms.

yearjournalcountryeditionlanguage
2009-10-16
http://hdl.handle.net/10447/53708