Oral contraceptives in the prevention of endometrioma recurrence: does the different progestins used make a difference?

6533b82afe1ef96bd128b92f

RESEARCH PRODUCT

Oral contraceptives in the prevention of endometrioma recurrence: does the different progestins used make a difference?

Pasquale De Franciscis Gabriele Tonni Alessandro Svelato Salvatore Saitta Antonino Perino Gaspare Cucinella Roberta Granese Gloria Calagna Nicola Colacurci

subject

minimally invasive gynecologic surgery Adult medicine.medical_specialty Endometriosis endometrioma recurrencee oral contraceptives minimally invasive gynecologic surgery progestins dienogest.Adolescent Norpregnenes endometrioma recurrencee Endometriosis Endometriosis Kaplan-Meier Estimate Drug Administration Schedule law.invention Young Adult chemistry.chemical_compound Randomized controlled trial law Secondary Prevention Humans Nandrolone Medicine In patient Ovarian Diseases Young adult Laparoscopy oral contraceptives Desogestrel medicine.diagnostic_test business.industry Obstetrics Obstetrics and Gynecology Endometriosis Endometrioma recurrence Oral contraceptives Minimally invasive gynaecologic surgery Progestins Dienogest General Medicine Laparoscopic excision medicine.disease Combined Modality Therapy Surgery Regimen Treatment Outcome Dienogest chemistry progestins dienogest Female Laparoscopy business Contraceptives Oral Follow-Up Studies

description

""The primary aim of the study was to analyze the endometrioma recurrence rate in patients who underwent laparoscopic excision followed by postoperative long-term regimen of oral contraceptives (OCs).. . MATERIALS AND METHODS: 168 patients who underwent a conservative laparoscopic surgery for endometrioma, during the period between September 2009 and August 2010 in three university hospitals were studied. A long-term OCs therapy was offered to all women following surgery. Patients were randomly divided into three groups according to different progestins used (desogestrel, gestodene, dienogest). Women who refused a postoperative hormonal therapy served as control. Follow-up visits and transvaginal scan were planned at 1, 3, 6, 12, and 24 months after surgery. All patients who showed an ultrasound persistence of the endometrioma at 1 month follow-up were excluded from clinical analysis.. . RESULTS: Of the 168 patients, 131 completed the 24 months follow-up. Endometrioma recurrence was found in 21 (12.5 %) of all patients, it was unilateral in 17 cases while bilateral in 4 cases. The rate of recurrent endometrioma was statistically significant in non-users compared to the long-term OCs treated patients.. . CONCLUSION: The current data suggest the usefulness of long-term OCs regimen after conservative surgery for the prevention of ovarian endometrioma recurrence. As a statistical significant difference could not be observed between OCs groups, further study on the individual molecules is required in order to really understand the effect of each of them.. . PMID:23580011[PubMed - as supplied by publisher] ""

year	journal	country	edition	language
2013-01-01

http://hdl.handle.net/11591/321117