Implication of corticotropic hormone axis in eating behaviour pattern in obese and type 2 diabetic participants.

6533b82afe1ef96bd128b94f

RESEARCH PRODUCT

Implication of corticotropic hormone axis in eating behaviour pattern in obese and type 2 diabetic participants.

Elhadj-ahmed Koceir Naim Akhtar Khan H Benbaïbeche Brahim Oudjit G. Kacimi El Mahdi Haffaf

subject

Blood Glucose Male medicine.medical_specialty Hydrocortisone medicine.medical_treatment Radioimmunoassay Medicine (miscellaneous)Adipose tissue Type 2 diabetes Diet Mediterranean Cohort Studies Insulin resistance Adrenocorticotropic Hormone Internal medicine Diabetes mellitus Surveys and Questionnaires medicine Humans Insulin Obesity Glycated Hemoglobin Metabolic Syndrome Nutrition and Dietetics Anthropometry business.industry Insulin Cholesterol HDL Cholesterol LDL Feeding Behavior medicine.disease Obesity Diet Endocrinology Diabetes Mellitus Type 2 Algeria Growth Hormone Multivariate Analysis Female Metabolic syndrome business Hormone

description

In Algeria, eating behaviour has been increasingly deviated from its traditional Mediterranean diet to modern fast food style. The present study examines the interactions between eating behaviour pattern (EBP), corticotropic hormone axis and the metabolic syndrome. Our Algerian population cohort comprised of 410 participants (130 obese, 170 type 2 diabetics and 110 healthy participants). The EBP was evaluated by the Three-Factor Eating Questionnaire test. The anthropometric and metabolic parameters (glucose, TAG, HDL, LDL and cholesterol) and the concentrations of hormones (insulin, adrenocorticotropin hormone (ACTH), cortisol and growth hormone) were determined by biometrics, spectrophotometry and RIA, respectively. Multivariate analyses showed a high correlation between the EBP and the metabolic syndrome, particularly between insulin-resistant state and hypertrophy of visceral adipose tissue. Compared with healthy participants, obese ones showed the hyperphagic type of EBP, i.e. disinhibition and hunger disorders. Conversely, the diabetics showed both the hypophagic and hyperphagic type of EBP. In diabetic and obese participants, cortisol and ACTH secretions were significantly altered, leading to metabolic disorders. The present study confirms the role of EBP in obesity and diabetes.

year	journal	country	edition	language
2015-03-19	The British journal of nutrition

10.1017/s0007114515000549 https://pubmed.ncbi.nlm.nih.gov/25782454