6533b82afe1ef96bd128b964
RESEARCH PRODUCT
New molecular catalysts for ATP cleavage. Criteria of size complementarity
Pilar DíazPaolo RomaniJose Antonio RamirezEnrique García-españaConxa SorianoAna B. DescalzoVieri FusiMauro MicheloniSantiago V. LuisJuan A. Aguilarsubject
chemistry.chemical_classificationHydrolysischemistry.chemical_compoundDeprotonationQuenching (fluorescence)chemistryStereochemistryNucleotideReceptorCleavage (embryo)CyclophaneCatalysisdescription
The interaction of the cyclophane receptor 2,5,8,11,14,17-hexaaza[18]metacyclophane (L) with the nucleotides ATP, ADP and AMP is described. L yields one of the largest rate enhancements for hydrolytic ATP cleavage observed in macrocyclic polyamines. The process is specific for the formation of ADP and involves a high degree of geometrical complementarity between host and guest species. The analogue compound 24-hydroxy-2,5,8,11,14,17-hexaaza[18]metacyclophane (L11) shows also a high degree of ATP activation. However, in this case deprotonation of the hydroxy group results in almost complete quenching of the ATPase activity above pH 7.0.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-01-01 |