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RESEARCH PRODUCT
Synthesis ofmeta-Terphenyl-2,2′′-diols by Anodic C−C Cross-Coupling Reactions
Siegfried R. WaldvogelSiegfried R. WaldvogelBernd ElslerRobert FrankeDieter SchollmeyerSebastian LipsAnton WiebeAnton WiebeKatrin Marie Dyballasubject
Electrolysis010405 organic chemistrySubstrate (chemistry)General Chemistry010402 general chemistryElectrochemistry01 natural sciencesCombinatorial chemistryCatalysisCoupling reaction0104 chemical scienceslaw.inventionPincer movementAnodechemistry.chemical_compoundchemistrylawTerphenylOrganic chemistryMoleculedescription
The anodic C-C cross-coupling reaction is a versatile synthetic approach to symmetric and non-symmetric biphenols and arylated phenols. We herein present a metal-free electrosynthetic method that provides access to symmetric and non-symmetric meta-terphenyl-2,2''-diols in good yields and high selectivity. Symmetric derivatives can be obtained by direct electrolysis in an undivided cell. The synthesis of non-symmetric meta-terphenyl-2,2''-diols required two electrochemical steps. The reactions are easy to conduct and scalable. The method also features a broad substrate scope, and a large variety of functional groups are tolerated. The target molecules may serve as [OCO](3-) pincer ligands.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-08-04 | Angewandte Chemie International Edition |