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RESEARCH PRODUCT
The cAMP pathway as therapeutic target in autoimmune and inflammatory diseases
Verena RakerChristian BeckerKerstin Steinbrinksubject
0301 basic medicinelcsh:Immunologic diseases. AllergyCell signalingT regulatory cellsImmunologyRegulatorT cellsTregsInflammationAutoimmunityReviewmedicine.disease_causeAutoimmunity03 medical and health scienceschemistry.chemical_compoundImmune systemmedicineCyclic AMPImmunology and AllergyCyclic adenosine monophosphateTregs; T regulatory CellsInflammationbusiness.industryCellular pathwaystargeted therapiesCell biology030104 developmental biologychemistryImmunologycAMP-dependent pathwaymedicine.symptombusinesslcsh:RC581-607description
Nucleotide signaling molecules contribute to the regulation of cellular pathways. In the immune system, cyclic adenosine monophosphate (cAMP) is well established as a potent regulator of innate and adaptive immune cell functions. Therapeutic strategies to interrupt or enhance cAMP generation or effects have immunoregulatory potential in autoimmune and inflammatory disorders. Here, we provide an overview of the cyclic AMP axis and its role as a regulator of immune functions and discuss the clinical and translational relevance of interventions with these processes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-03-31 | Frontiers in Immunology |