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RESEARCH PRODUCT
Diabetes and Dementia
Ligia J. DominguezMario Barbagallosubject
medicine.medical_specialtybusiness.industryPhysiologyType 2 Diabetes MellitusHypoglycemiamedicine.diseaseAsymptomaticEndocrinologyInsulin resistanceInternal medicineDiabetes mellitusmedicineHyperinsulinemiaDementiamedicine.symptomCognitive declinebusinessdescription
Persons with type 2 diabetes mellitus (DM2) have an increased incidence of cognitive decline and dementia. An increased cortical and subcortical atrophy has been found after controlling for vascular disease and inadequate cerebral circulation. A possible role of insulin resistance and hyperinsulinemia has been suggested to mediate the link between DM2 and Alzheimer’s Disease (AD). Altered insulin signaling may contribute to AD biochemical and histopathological lesions. Both hyperglycemia and hypoglycemia may contribute to cognitive decline in DM2. Recurrent symptomatic and asymptomatic hypoglycemic episodes have been suggested to cause subclinical brain damage, and permanent cognitive impairment. Future trials are needed to clarify if cognitive decline may be prevented by an adequate metabolic control, insulinsensitizing agents and avoiding hypoglycemia.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-08-31 | International Journal of Diabetes and Clinical Research |