6533b82afe1ef96bd128bfee

RESEARCH PRODUCT

Significance and relevance of serum preS1 antigen detection in wild-type and variant hepatitis B virus (HBV) infections

G. GerkenFrancis CapelC. TrepoChristian BréchotSylvie DubanchetMarie-anne Petit

subject

Infectivitybusiness.industryAntiviral therapyWild typevirus diseasesVirologydigestive system diseasesVirusPersistence (computer science)Chronic infectionAntigenHepatitis B virus HBVMedicinebusiness

description

These studies assessed whether the serum expression of preS1 antigen could be a useful HBV marker for monitoring the progress of antiviral therapy in the treatment of chronic active hepatitis B (CAH-B) virus infections. Our findings indicate that: 1) the rearrangements we observed in the preS region of mutated HBV DNA molecules during chronic infection did not effect the preS1 sequence (21–47) critical for HBV infectivity; 2) the persistence or even the rebound of preS1 antigen expression during follow-up in responders to antiviral therapy may indicate virus persistence, suggesting the possibility of relapse through wild-type HBV or the emergence of HBV variants following the immunoelimination phase.

yearjournalcountryeditionlanguage
1993-01-01
https://doi.org/10.1007/978-3-7091-9312-9_18