6533b82afe1ef96bd128c0d6

RESEARCH PRODUCT

Enzymatic glycosylation of o-glycopeptides

M. SchultzHorst Kunz

subject

chemistry.chemical_classificationGlycosylationbiologyStereochemistryOrganic ChemistryLactose synthaseBiochemistryChemical synthesisGlycopeptidecarbohydrates (lipids)Serinechemistry.chemical_compoundEnzymechemistryGlucosamineDrug Discoverybiology.proteinOrganic chemistrylipids (amino acids peptides and proteins)Stereoselectivity

description

Abstract O-Glycosylation of serine derivatives carried out with N-urethane protected glucosamine yields O-glycopeptides which are regio- and stereoselectively galactosylated with the aid of β-1,4-galactosyltransferase (EC 2.4.1.22).

https://doi.org/10.1016/s0040-4039(00)79082-4