Formation and function of a complement-activating enzyme generated from factors of guinea pig serum and cobra venom

6533b82afe1ef96bd128c1b8

RESEARCH PRODUCT

Formation and function of a complement-activating enzyme generated from factors of guinea pig serum and cobra venom

Dieter Bitter-suermann W. König Ulrich Hadding Manfred P. Dierich

subject

chemistry.chemical_classification Venoms Cell Membrane Guinea Pigs Immunology Snakes Complement System Proteins Biology Chromatography DEAE-Cellulose Enzymes Complement components Complement (complexity)Guinea pig Enzyme Membrane Biochemistry chemistry Cell surface receptor Animals Immunology and Allergy Magnesium Function (biology)Cobra venom

description

An enzymatic complex can be formed by factors from guinea pig serum and cobra venom, which is able to activate C3 bypassing C1, C4 and C2. Formation and action of the enzyme are described. The action on C3 results in an activation of the terminal complement components and in membrane destruction provided suitable membrane receptors are available.

year	journal	country	edition	language
1971-08-01	European Journal of Immunology

https://doi.org/10.1002/eji.1830010421

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