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RESEARCH PRODUCT
Lithium prevents grey matter atrophy in patients with bipolar disorder: an international multicenter study
Frank BellivierAmelia VersaceMarcella BellaniSamuel SarrazinMelissa PaulingLouise EmsellCharles LaidiJean-françois ManginPaolo BrambillaFranz HozerMarine DelavestPauline FavreColm McdonaldMary L. PhillipsMichèle WessaNora HamdaniJulia LinkeMarion LeboyerMarc Antoine D'albisDara M. CannonMircea PolosanJosselin HouenouEdouard Duchesnaysubject
AdultMalemedicine.medical_specialtyBipolar DisorderLithium (medication)[SDV]Life Sciences [q-bio]UrologyGrey matterGyrus CinguliHippocampus03 medical and health sciences0302 clinical medicineAtrophyAntimanic AgentsmedicineHumansIn patientBipolar disorderGray MatterPathologicalApplied PsychologyComputingMilieux_MISCELLANEOUSGrey matter atrophybusiness.industryConfoundinggrey matter volumeMiddle Agedmedicine.diseaseMagnetic Resonance ImagingTemporal Lobe3. Good health030227 psychiatryPsychiatry and Mental healthmedicine.anatomical_structurelithiumCase-Control StudiesLithium CompoundsFemaleAtrophybusiness030217 neurology & neurosurgeryMRImedicine.drugdescription
AbstractBackgroundLithium (Li) is the gold standard treatment for bipolar disorder (BD). However, its mechanisms of action remain unknown but include neurotrophic effects. We here investigated the influence of Li on cortical and local grey matter (GM) volumes in a large international sample of patients with BD and healthy controls (HC).MethodsWe analyzed high-resolution T1-weighted structural magnetic resonance imaging scans of 271 patients with BD type I (120 undergoing Li) and 316 HC. Cortical and local GM volumes were compared using voxel-wise approaches with voxel-based morphometry and SIENAX using FSL. We used multiple linear regression models to test the influence of Li on cortical and local GM volumes, taking into account potential confounding factors such as a history of alcohol misuse.ResultsPatients taking Li had greater cortical GM volume than patients without. Patients undergoing Li had greater regional GM volumes in the right middle frontal gyrus, the right anterior cingulate gyrus, and the left fusiform gyrus in comparison with patients not taking Li.ConclusionsOur results in a large multicentric sample support the hypothesis that Li could exert neurotrophic and neuroprotective effects limiting pathological GM atrophy in key brain regions associated with BD.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-01 |