6533b82afe1ef96bd128c1d5
RESEARCH PRODUCT
Solid variant of mammary "adenoid cystic carcinoma with basaloid features" merging with "small cell carcinoma"
Salvatore FricanoElisabetta BarresiVito RodolicoCalogero CipollaAda Maria FlorenaL. NapoliDaniela CabibiSalvatore Vienisubject
AdultPathologymedicine.medical_specialtyAdenoid cystic carcinoma2734Breast NeoplasmsBiologyHistogenesisSettore MED/08 - Anatomia PatologicaMastectomy SegmentalSmall-cell carcinomaPathology and Forensic MedicineNeoplasms Multiple PrimaryBiomarkers TumormedicineCarcinomaHumansBreastCarcinoma Small CellneoplasmsSmall cell carcinomaMyoepithelial cellChromogranin ABasaloid adenoid cystic carcinomaCell BiologyPeriodic Acid-Schiff Reactionmedicine.diseaseCarcinoma Adenoid CysticImmunohistochemistrystomatognathic diseasesSettore MED/18 - Chirurgia GeneraleCarcinoma Basal CellChemotherapy AdjuvantAxillaSynaptophysinbiology.proteinLymph Node ExcisionImmunohistochemistryFemaleBasaloid adenoid cystic carcinoma; Breast; Small cell carcinoma; Adult; Axilla; Biomarkers Tumor; Breast Neoplasms; Carcinoma Adenoid Cystic; Carcinoma Basal Cell; Carcinoma Small Cell; Chemotherapy Adjuvant; Female; Humans; Immunohistochemistry; Lymph Node Excision; Mastectomy Segmental; Neoplasms Multiple Primary; Periodic Acid-Schiff Reaction; 2734Breast NeoplasmHumandescription
We describe a rare case of a solid variant of a mammary adenoid cystic carcinoma with basaloid features (sbACC) and its coexistence with a "small cell" carcinoma (SCC), identified and confirmed by histological and immunohistochemical observations: the absence of glandular structures and PAS-positive globules, positivity for neuroendocrine markers (NSE, synaptophysin and chromogranin), and negativity for 34betaE12 and SMA actin were the aspects suggesting the presence of SCC. Furthermore, positivity for CD10 was found both in sbA CC and in SCC, supporting the hypothesis that the two components share the same histogenetic myoepithelial origin and represent an example of dedifferentiation along neuroendocrine phenotype lines occurring in a multipotential neoplastic stem line, already committed towards a myoepithelial phenotype. To our knowledge, this is the first reported c ase of a solid basaloid adenoid cystic carcinoma merging with an SCC carcinoma. Furthermore, it is the first study in which CD10 was used to investigate the histogenesis of the two neoplastic components. © 2005 Elsevier GmbH. All rights reserved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-10-01 |