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RESEARCH PRODUCT

Metabolic response to 6-week aerobic exercise training and dieting in previously sedentary overweight and obese pre-menopausal women: A randomized trial

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AbstractBackground: The aim of this study was to compare 6 weeks short-term moderate intensity aerobic exercise and dieting on serum metabolomicsand cardio-metabolic risk factors in pre-menopausal women.Methods: Ninety previously inactive overweight and obese (BMI 25e35 kg/m 2 ) women (age 41.5 7.6 years) were randomized to either a6-week Nordic walking exercise program (EX, n ¼ 45) or dietary counseling group (DI, n ¼ 45). Body composition, serum glucose, insulin andlipids were measured. Serum low-molecular-weight metabolites and lipid constituents were analyzed by nuclear magnetic resonance spec-troscopy. Measurements were done at baseline and 7 days after the last training session.Results: Six weeks aerobic exercise program yielded reductions in serum free fatty acids ( 34.7%, 95% confidence interval (CI), 50 to 18,p < 0.001), glucose ( 9.6%, 95%CI, 15 to 4, p < 0.001) and homeostasis model assessment of insulin resistance (HOMA-IR) ( 28.7%,95% CI, 48 to 10, p ¼ 0.005) without changes in body weight or fat mass. Diet counseling resulted in loss of body weight (1.5%, 95%CI, 2.3 to 0.7, p ¼ 0.001) but no changes in free fatty acids, fasting glucose, or HOMA-IR were found.Conclusion: Our results indicate that small weight loss does not produce measurable health benefits, whereas short-term regular aerobic exercisecan improve glucose and lipid metabolism even in the absence of weight loss in previously sedentary overweight and obese women.Copyright 2014, Shanghai University of Sport. Production and hosting by Elsevier B.V. All rights reserved.