6533b82afe1ef96bd128c2ba

RESEARCH PRODUCT

Comparative effects of estradiol, raloxifene, and genistein on the uterus of ovariectomized mice.

Carlos EhermenegildoInmaculada NogueraMiguel Angel García-pérezAntonio CanoRaquel Del ValRosa Noguera

subject

medicine.medical_specialtymedicine.drug_classOvariectomyUterusGenisteinEstrogen receptorBiologyEndometriumchemistry.chemical_compoundMiceInternal medicinemedicineAnimalsRaloxifeneintegumentary systemEstradiolBody WeightUterusObstetrics and GynecologyAntiestrogenGenisteinMice Inbred C57BLmedicine.anatomical_structureEndocrinologyReproductive MedicinechemistryEstrogenRaloxifene HydrochlorideOvariectomized ratFemalemedicine.drug

description

To explore the uterine effects of administration of compounds that exert their bone-sparing functions through estrogen receptors, we administered 17beta-E2, raloxifene, or genistein to ovariectomized mice and analyzed the uterus weight and histology 4 weeks after beginning the treatments. Results indicated that raloxifene and genistein have partial agonistic properties on the uterus in estrogen-depleted mice, and that genistein induced apoptosis and several atypias in the glandular epithelium of endometrium, as demonstrated in hematoxylin-eosin-stained histological sections.

yearjournalcountryeditionlanguage
2005-12-23Fertility and sterility
10.1016/j.fertnstert.2006.03.029https://pubmed.ncbi.nlm.nih.gov/16963036