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RESEARCH PRODUCT

Invasive candida infections in neonates after major surgery: Current evidence and new directions

Domenico Umberto De RoseAlessandra SantisiMaria Paola RonchettiLudovica MartiniLisa SerafiniPasqua BettaMarzia MainoFrancesco CavigioliIlaria CocchiLorenza PugniElvira BonannoChryssoula TziallaMario GiuffrèJenny BuaBenedetta Della TorreGiovanna NardellaDanila MazzeoPaolo ManzoniAndrea DottaPietro BagolanCinzia AuritiOn Behalf Of Study Group Of Neonatal Infectious Diseases

subject

0301 basic medicineMicrobiology (medical)Antifungalmedicine.medical_specialtymedicine.drug_classInvasive Candida infections030106 microbiologylcsh:MedicineInvasive Candida infectionCandida infections03 medical and health sciencesBroad spectrumNeonatal surgeryinvasive <i>Candida</i> infections0302 clinical medicineInvasive fungal infectionInvasive fungal infectionsIntensive careEpidemiologyFungal colonizationImmunology and AllergyMedicineAntifungal prophylaxi030212 general & internal medicineMolecular BiologyNewbornsGeneral Immunology and Microbiologybusiness.industrylcsh:RImpaired immune responsesNewbornSurgeryNeonatal surgeryInfectious DiseasesSettore MED/20SurgeryAntifungal prophylaxisAntifungal prophylaxis; Invasive Candida infections; Invasive fungal infections; Neonatal surgery; Newborns; Surgerybusiness

description

Infections represent a serious health problem in neonates. Invasive Candida infections (ICIs) are still a leading cause of mortality and morbidity in neonatal intensive care units (NICUs). Infants hospitalized in NICUs are at high risk of ICIs, because of several risk factors: broad spectrum antibiotic treatments, central catheters and other invasive devices, fungal colonization, and impaired immune responses. In this review we summarize 19 published studies which provide the prevalence of previous surgery in neonates with invasive Candida infections. We also provide an overview of risk factors for ICIs after major surgery, fungal colonization, and innate defense mechanisms against fungi, as well as the roles of different Candida spp., the epidemiology and costs of ICIs, diagnosis of ICIs, and antifungal prophylaxis and treatment.

yearjournalcountryeditionlanguage
2021-01-01
10.3390/pathogens10030319http://hdl.handle.net/10447/499485