0000000000668707

AUTHOR

Danila Mazzeo

showing 2 related works from this author

Invasive candida infections in neonates after major surgery: Current evidence and new directions

2021

Infections represent a serious health problem in neonates. Invasive Candida infections (ICIs) are still a leading cause of mortality and morbidity in neonatal intensive care units (NICUs). Infants hospitalized in NICUs are at high risk of ICIs, because of several risk factors: broad spectrum antibiotic treatments, central catheters and other invasive devices, fungal colonization, and impaired immune responses. In this review we summarize 19 published studies which provide the prevalence of previous surgery in neonates with invasive Candida infections. We also provide an overview of risk factors for ICIs after major surgery, fungal colonization, and innate defense mechanisms against fungi, a…

0301 basic medicineMicrobiology (medical)Antifungalmedicine.medical_specialtymedicine.drug_classInvasive Candida infections030106 microbiologylcsh:MedicineInvasive Candida infectionCandida infections03 medical and health sciencesBroad spectrumNeonatal surgeryinvasive <i>Candida</i> infections0302 clinical medicineInvasive fungal infectionInvasive fungal infectionsIntensive careEpidemiologyFungal colonizationImmunology and AllergyMedicineAntifungal prophylaxi030212 general & internal medicineMolecular BiologyNewbornsGeneral Immunology and Microbiologybusiness.industrylcsh:RImpaired immune responsesNewbornSurgeryNeonatal surgeryInfectious DiseasesSettore MED/20SurgeryAntifungal prophylaxisAntifungal prophylaxis; Invasive Candida infections; Invasive fungal infections; Neonatal surgery; Newborns; Surgerybusiness
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Association of maternal hypertension and chorioamnionitis with preterm outcomes

2014

OBJECTIVES: We compared the relative effect of hypertensive disorders of pregnancy and chorioamnionitis on adverse neonatal outcomes in very preterm neonates, and studied whether gestational age (GA) modulates these effects. METHODS: A cohort of neonates 23 to 30 weeks' GA, born in 2008 to 2011 in 82 hospitals adhering to the Italian Neonatal Network, was analyzed. Infants born from mothers who had hypertensive disorders (N = 2096) were compared with those born after chorioamnionitis (N = 1510). Statistical analysis employed logistic models, adjusting for GA, hospital, and potential confounders. RESULTS: Overall mortality was higher after hypertension than after chorioamnionitis (odds rati…

MalePediatricsLogistic models; Mortality; Outcomes; Pregnancy complications; Preterm infants; Risks; Female; Gestational Age; Humans; Infant Newborn; Infant Premature Diseases; Male; Pregnancy; Pregnancy Outcome; Prospective Studies; Chorioamnionitis; Hypertension Pregnancy-Induced; Pediatrics Perinatology and Child Health; Medicine (all); Arts and Humanities (miscellaneous)DiseasesInfant Premature DiseasesChorioamnionitisoutcomesPediatricsPregnancyRisksMaternal hypertensionProspective StudiesriskObstetricspregnancy complicationsMedicine (all)Pregnancy OutcomeGestational ageRetinopathy of prematurityPerinatology and Child HealthChorioamnionitisSettore MED/38 - PEDIATRIA GENERALE E SPECIALISTICALogistic models Mortality Outcomes Pregnancy complications Preterm infants RisksNecrotizing enterocolitisHypertensionoutcomeFemaleHumanmedicine.medical_specialtyGestational AgeOutcomesPregnancy-Inducedpreterm infantPregnancy complicationArts and Humanities (miscellaneous)medicineLogistic models; Mortality; Outcomes; Pregnancy complications; Preterm infants; Risks; Female; Gestational Age; Humans; Infant Newborn; Infant Premature Diseases; Male; Pregnancy; Pregnancy Outcome; Prospective Studies; Chorioamnionitis; Hypertension Pregnancy-Induced; Pediatrics Perinatology and Child HealthHumanspreterm infantsMortalityPrematurelogistic modelPregnancyChorioamnionitibusiness.industryInfant NewbornPreterm infantsInfantInfant Premature DiseaseOdds ratioHypertension Pregnancy-Inducedmedicine.diseaseNewbornmortalityLogistic modelsProspective StudiePregnancy complicationsBronchopulmonary dysplasiaPediatrics Perinatology and Child Healthbusinesslogistic modelsrisks
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