6533b82afe1ef96bd128c416
RESEARCH PRODUCT
Role of bacteria-specific T cells in the immunopathogenesis of reactive arthritis.
Elisabeth HermannBernhard FleischerPeter Probstsubject
Microbiology (medical)Antigens BacterialImmunity CellularbiologyYersinia InfectionsSterile inflammationT-LymphocytesCD8-Positive T-Lymphocytesbiology.organism_classificationmedicine.diseaseMicrobiologyArthritis ReactiveRatsInfectious DiseasesVirologyImmunologySalmonella InfectionsmedicineAnimalsHumansReactive arthritisBacterial antigenTh1 responseBacteriadescription
Reactive arthritis is a usually self-limited sterile inflammation of joints that follows certain bacterial gastrointestinal or urogenital infections. The immunopathogenesis involves CD4+ T cells, which mediate an antigen-specific TH1 response to bacterial constituents within the joint. Properties of the arthritogenic bacteria and the physicochemical characteristics of the bacterial antigens may contribute to the development of reactive arthritis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1994-09-01 | Trends in microbiology |