VHL gēna mutācijas gaišo šūnu nieru karcinomas gadījumā

6533b82afe1ef96bd128c651

RESEARCH PRODUCT

VHL gēna mutācijas gaišo šūnu nieru karcinomas gadījumā

subject

gaišo šūnu nieru karcinoma Farmācija clear cell renal cell carcinoma von Hippel-Lindau

description

Nieru šūnu karcinoma ir sestais biežāk diagnosticētais audzējs no visām onkoloģiskajām diagnozēm pasaulē. Gaišo šūnu nieru karcinoma ir 65-70% no visiem saslimšanas gadījumiem ar nieru audzējiem. Izmaiņas von Hippel-Lindau (VHL) gēnā, kurš ir visbiežāk mutētais gēns gaišo šūnu nieru karcinomas gadījumā, tiek salīdzinātas starp in vitro audzētām cilvēku nieru proksimālo kanāliņu epitēlija šūnām un gaišo šūnu nieru karcinomas šūnu līnijām un primārajām šunām, kuras iegūtas no gaišo šūnu nieru karcinomas pacientu audiem un blakus esošiem veselajiem audiem. Darba rezultātā tika konstatēts viena nukleotīda polimorfisms pacientu gaišo šūnu nieru karcinomas audos un veselajos audos no VHL gēna izolētajā 1.eksonā.

year	journal	country	edition	language
2019-01-01

https://dspace.lu.lv/dspace/handle/7/48698

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
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