6533b82afe1ef96bd128cb25

RESEARCH PRODUCT

Anticoagulant Activity of the Enantiomers of Acenocoumarol in Man

Eberhard JähnchenJ RichardWolfgang KasperThomas MeinertzJ Godbillon

subject

Acenocoumarolmedicine.drug_classChemistryAnticoagulantWarfarinPharmacologyGlucaric AcidPharmacokineticsmedicinePotencyheterocyclic compoundsStereoselectivityEnantiomermedicine.drug

description

For the mono-coumarin derivatives warfarin and phen-procoumon it was shown that in man and rats the S(−) enantiomer is several times more potent as anticoagulant than the R(+) enantiomer. These stereoselective differences in the anticoagulant potency reflect differences in the affinity for the receptor site rather than differences in the pharmacokinetics.

yearjournalcountryeditionlanguage
1978-01-01
https://doi.org/10.1007/978-3-662-39532-5_258