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RESEARCH PRODUCT

Nuclease activity of [Cu(sulfathiazolato)2(benzimidazole)2]2MeOH. Synthesis, properties and crystal structure

Malva Liu-gonzálezM. Del OlmoBenigno MacíasGloria AlzuetJoaquín BorrásMarta González-álvarezFrancisco Sanz

subject

Models MolecularBenzimidazoleSpectrophotometry InfraredReducing agentMolecular Conformationchemistry.chemical_elementCrystal structureCrystallography X-RayCleavage (embryo)BiochemistryDithiothreitolInorganic ChemistryStructure-Activity Relationshipchemistry.chemical_compoundSulfathiazoleOrganometallic CompoundsGroup 2 organometallic chemistrySulfathiazolesDeoxyribonucleasesMethanolElectron Spin Resonance SpectroscopyCopperCrystallographychemistryBenzimidazolesCopperPlasmidsMonoclinic crystal system

description

The [Cu(sulfathiazolato)(2)(benzimidazole)(2)]2MeOH complex has been synthesised and characterised. It crystallises in the monoclinic system, space group C1c1, with unit cell dimensions a=18.829(7) A, b=12.206(3) A, c=17.233(5) A, alpha=90.06(2) degrees, beta=97.28(3) degrees, gamma=90.21(3) degrees and Z=4. The geometry around the copper(II) ion is intermediate between tetrahedral and square planar. The complex produces cleavage of plasmid pUC18 in presence of reducing agents. The efficiency of cleavage reaction of the title compound with pUC18 and with different reducing agents follows the order ascorbate-H(2)O(2)>ascorbate>MPA>dithiothreitol>H(2)O(2).

yearjournalcountryeditionlanguage
2002-04-05Journal of Inorganic Biochemistry
https://doi.org/10.1016/s0162-0134(01)00369-5