Endogenous noradrenaline release from guinea-pig isolated trachea is inhibited by activation of M2 receptors

6533b82afe1ef96bd128cc0c

RESEARCH PRODUCT

Endogenous noradrenaline release from guinea-pig isolated trachea is inhibited by activation of M2 receptors

Ignaz Wessler Claudia Hey Kurt Racké

subject

Male Agonist medicine.medical_specialty medicine.drug_class Guinea Pigs Muscarinic Antagonists Diamines In Vitro Techniques Inhibitory postsynaptic potential Guinea pig Norepinephrine chemistry.chemical_compound Piperidines Internal medicine Muscarinic acetylcholine receptor Methoctramine medicine Oxotremorine Animals Pharmacology Dose-Response Relationship Drug Oxotremorine Parasympatholytics Muscarinic acetylcholine receptor M2 Pirenzepine Receptors Muscarinic Pirenzepine Trachea Endocrinology chemistry Female Research Article medicine.drug

description

Overflow of endogenous noradrenaline (NA) from guinea-pig isolated tracheae was evoked by electrical field stimulation (3 Hz, 540 pulses). The muscarinic receptor agonist oxotremorine inhibited the evoked overflow of NA in a concentration-dependent manner (EC50 84 nM). Methoctramine, pirenzepine and p-fluoro-hexahydrosiladiphenidol (each 1 microM) shifted the concentration-response curves of oxotremorine to the right with apparent pA2 values of 7.60, 6.74 and 6.18, respectively. It is concluded that sympathetic nerve terminals in the guinea-pig trachea are endowed with inhibitory muscarinic M2 receptors.

year	journal	country	edition	language
1992-09-01	British Journal of Pharmacology

https://doi.org/10.1111/j.1476-5381.1992.tb14454.x

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