6533b82afe1ef96bd128ccb1
RESEARCH PRODUCT
Regulation of serotonin release from the intestinal mucosa.
Harald SchwörerKurt Rackésubject
endocrine systemmedicine.medical_specialtySerotoninVasoactive intestinal peptideBiology03 medical and health scienceschemistry.chemical_compound0302 clinical medicineIntestinal mucosaInternal medicinemedicineAnimalsHumansIntestinal MucosaReceptor5-HT receptor030304 developmental biologyPharmacology0303 health sciencesMuscarine3. Good healthEndocrinologychemistryEnterochromaffin cellSerotonin030217 neurology & neurosurgeryAcetylcholinemedicine.drugdescription
Summary In the mammalian intestine serotonin (5-hydroxytryptamine, 5-HT) is present in high concentrations in the enterochromaffin cells. The release of 5-HT from the intestinal mucosa is regulated by a complex pattern of neuronal and humoral inputs to the enterochromaffin cells. The enterochromaffin cells appear to be endowed with different inhibitory ( α 2 -adrenoceptors, GABA A - and GABA B -receptors, histamine H 3 -receptors, receptors for vasoactive intestinal polypeptide and somatostatin) as well as stimulatory receptors ( β -adrenoceptors, muscarine and nicotine receptors). The physiological significance of this complex system of receptors is suggested by experiments which demonstrate that the respective intrinsic neurotransmitters (catecholamines, acetylcholine, GABA and vasoactive intestinal polypeptide) released within the gut are involved in the regulation of the release of 5-HT from the enterochromaffin cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-01-01 | Pharmacological research |