Peptīdu lunasīna un RGD regulējošā darbība peļu šizofrēnijas modeļos

6533b82bfe1ef96bd128d124

RESEARCH PRODUCT

Peptīdu lunasīna un RGD regulējošā darbība peļu šizofrēnijas modeļos

subject

RGD lokomotorā aktivitāte Farmācija Lunasīns centrālā nervu sistēma

description

Lunasīns ir bioloģiski aktīvs peptīds, kam piemīt antioksidatīvas, pretiekaisuma, pretvēža un holesterīna biosintēzi regulējošas īpašības. Nesen atklāts, ka tas spēj ietekmēt arī centrālo nervu sistēmu, izmainot peļu uzvedību, tādējādi radās interese pētīt lunasīna un tā sastāvā esošā tripeptīda RGD centrālos efektus. Maģistra darba mērķis bija pētīt intranazāli ievadītu peptīdu lunasīna un RGD darbību peļu šizofrēnijas modeļos, izmantojot atvērtā lauka testu un nosakot VMAT2 ekspresiju ar Western blot metodi. Iegūtie rezultāti rāda, ka gan lunasīns, gan RGD samazina amfetamīna un DOI izraisīto peļu horizontālo lokomotoro hiperaktivitāti, bet neietekmē fenciklidīna izraisīto vispārējo horizontālo lokomotoro hiperaktivitāti atvērtā lauka testā. Peļu smadzeņu corpus striatum netika konstatēta VMAT2 proteīna ekspresija.

year	journal	country	edition	language
2018-01-01

https://dspace.lu.lv/dspace/handle/7/40227

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