6533b82bfe1ef96bd128d48f

RESEARCH PRODUCT

ChemInform Abstract: Facile Synthesis of 2-Nitroalkanols by Tetramethylguanidine (TMG)- Catalyzed Addition of Primary Nitroalkanes to Aldehydes and Alicyclic Ketones.

Marinella RobertiR. FerroniGian Piero PolliniStefano ManfrediniFrancesco Paolo InvidiataIlaria LamprontiDaniele Simoni

subject

chemistry.chemical_classificationAlicyclic compoundAddition reactionPrimary (chemistry)Nitroaldol reactionChemistryOrganic chemistryGeneral MedicineCatalysis

description

Abstract Tetramethylguanidine-catalyzed addition of primary nitroalkanes to aldehydes and alicyclic ketones constitutes a practical means to perform the nitro-aldol reaction (Henry reaction). The very mild conditions employed, together with the short reaction times, make the procedure tolerant of a range of functionalities and highly versatile for the synthesis of a variety of 2-nitroalkanols.

yearjournalcountryeditionlanguage
2010-08-03ChemInform
https://doi.org/10.1002/chin.199731089