6533b82bfe1ef96bd128d4eb
RESEARCH PRODUCT
Triazolopyridines. 14. Substitution reactions of 7-amino[1,2,3]triazolo[1,5-a]pyridines.
Gurnos JonesAmparo AsensioBelén AbarcaMichael B. HursthouseK. M. Abdul Maliksubject
Substitution reactionbiologyBicyclic moleculeOrganic ChemistryHalogenationBiochemistryMedicinal chemistrychemistry.chemical_compoundchemistryDrug DiscoveryPyridineX-ray crystallographybiology.proteinTriazolopyridineDerivative (chemistry)Organic aniondescription
Abstract Reaction between 7-aminotriazolopyridines 1 or 2 and sulphuric acid gives hydroxyalkylpyridines 3 and 4 ; bromination gives brominated pyridine 5 or triazolopyridine 6. The anions from amines 1 or 2 are ambident, acylating on N but alkylating on N or on C6; in the latter case triazolylalkenylcyanides 16 – 20 or the 6,6-dialkylated derivative 19 are obtained. An X-ray diffraction study has confirmed structure 19.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-01-01 | Tetrahedron |