6533b82bfe1ef96bd128d641

RESEARCH PRODUCT

Immune effects of 5-fluorouracil

François GhiringhelliMélanie BruchardLionel Apetoh

subject

IL1business.industryImmunologychemical and pharmacologic phenomenaInflammasomemyeloid derived suppressor cellsfluorouracillaw.inventionImmune systemNLRP3OncologyinflammasomelawTumor progressionImmunityFluorouracilImmunologyMyeloid-derived Suppressor CellmedicineImmunology and AllergyCytotoxic T cellSuppressorbusinessAuthor's Viewmedicine.drug

description

Cytotoxic anticancer drugs can promote antitumor immune responses. The anticancer activity of 5-fluorouracil (5FU) relies on the restoration of T-cell immunity following the elimination of myeloid-derived suppressor cells (MDSCs). We have recently discovered that the 5FU-driven activation of the NLRP3 inflammasome in MDSCs promotes tumor angiogenesis by eliciting TH17 responses that compromise anticancer immunity. This underscores the need to combine 5-FU with NLRP3 inhibitors to prevent tumor progression.

https://doi.org/10.4161/onci.23139