6533b82bfe1ef96bd128d7a2

RESEARCH PRODUCT

Medical history, lifestyle, family history, and occupational risk factors for chronic lymphocytic leukemia/small lymphocytic lymphoma: The InterLymph non-Hodgkin lymphoma subtypes project

Susan L. SlagerYolanda BenaventeAaron BlairRoel VermeulenJames R. CerhanAdele Seniori CostantiniAlain MonnereauAlexandra NietersJacqueline ClavelTimothy G. CallMarc MaynadiéQing LanChristina A. ClarkeTracy LightfootAaron D. NormanJoshua N. SampsonDelphine CasabonnePierluigi CoccoSilvia De SanjoséLs Iras Eepi Gra (Gezh.risico-analyse)Risk Assessment Of Toxic And Immunomodulatory AgentsIras Ratia-sib

subject

AdultMaleOncologymedicine.medical_specialtyCancer ResearchChronic lymphocytic leukemiaComorbidityArticleYoung AdultRisk FactorsOccupational ExposureInternal medicinehemic and lymphatic diseasesOdds RatiomedicineHumansMedical historyFamily historyYoung adultLife StyleAgedAged 80 and overbusiness.industryAustraliaCase-control studyGeneral MedicineOdds ratioMiddle Agedmedicine.diseaseLeukemia Lymphocytic Chronic B-CellLymphomaEuropeOncologyCase-Control StudiesMeta-analysisNorth AmericaImmunologyFemalebusiness

description

Background: Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are two subtypes of non-Hodgkin lymphoma. A number of studies have evaluated associations between risk factors and CLL/SLL risk. However, these associations remain inconsistent or lacked confirmation. This may be due, in part, to the inadequate sample size of CLL/SLL cases. Methods: We performed a pooled analysis of 2440 CLL/SLL cases and 15 186 controls from 13 case-control studies from Europe, North America, and Australia. We evaluated associations of medical history, family history, lifestyle, and occupational risk factors with CLL/SLL risk. Multivariate logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: We confirmed prior inverse associations with any atopic condition and recreational sun exposure. We also confirmed prior elevated associations with usual adult height, hepatitis C virus seropositivity, living or working on a farm, and family history of any hematological malignancy. Novel associations were identified with hairdresser occupation (OR = 1.77, 95% CI = 1.05 to 2.98) and blood transfusion history (OR = 0.79, 95% CI = 0.66 to 0.94). We also found smoking to have modest protective effect (OR = 0.9, 95% CI = 0.81 to 0.99). All exposures showed evidence of independent effects. Conclusions: We have identified or confirmed several independent risk factors for CLL/SLL supporting a role for genetics (through family history), immune function (through allergy and sun), infection (through hepatitis C virus), and height, and other pathways of immune response. Given that CLL/SLL has more than 30 susceptibility loci identified to date, studies evaluating the interaction among genetic and nongenetic factors are warranted.

yearjournalcountryeditionlanguage
2014-08-01
10.1093/jncimonographs/lgu001https://dspace.library.uu.nl/handle/1874/305019