6533b82bfe1ef96bd128d89d

RESEARCH PRODUCT

Immunohistological differential diagnosis of inflammatory colonic diseases.

Stephan StörkelM. GrossM. LoosH.-m. Schneider

subject

Immunoglobulin Amedicine.medical_specialtyPathologyHistologyComplement Activating EnzymesGastroenterologyPathology and Forensic MedicinePathogenesisDiagnosis DifferentialCrohn DiseaseInternal medicinemedicineHumansColitisCrohn's diseasebiologybusiness.industryHistocytochemistryComplement C1qImmunochemistryComplement C4General MedicineComplement C3medicine.diseaseColitisUlcerative colitisdigestive system diseasesImmunoglobulin AImmunoglobulin MImmunoglobulin Mbiology.proteinImmunohistochemistryColitis UlcerativeAntibodybusinessGranulocytes

description

Immunohistological investigations were carried out on human colonic tissue from, I healthy mucosa, 2 slightly inflamed mucosa, 3 mucosa with ulcerative colitis, 4 mucosa with Crohn's colitis, using antibodies against immunoglobulins and complement components. All our antibodies, including F(ab')2 fragments, demonstrated a progressive increase of labelled cells from healthy mucosa through slightly inflamed mucosa to mucosa with ulcerative colitis, in contrast to a complete absence of labelled cells in cases of Crohn's disease. The results are discussed with regard to their pathogenesis and their clinical significance for the differentiation of ulcerative colitis and Crohn's colitis.

yearjournalcountryeditionlanguage
1984-07-01Histopathology
10.1111/j.1365-2559.1984.tb02370.xhttps://pubmed.ncbi.nlm.nih.gov/6332771