6533b82bfe1ef96bd128d8a1
RESEARCH PRODUCT
A Versatile Palladium/Triphosphane System for Direct Arylation of Heteroarenes with Chloroarenes at Low Catalyst Loading
Sophal MomHenri DoucetMatthieu BeaupérinJean-cyrille HiersoDavid Roysubject
chemistry.chemical_elementRing (chemistry)010402 general chemistry01 natural sciencesCatalysisCatalysischemistry.chemical_compound[ CHIM.CATA ] Chemical Sciences/CatalysisBromidePolymer chemistryOrganic chemistryheterocyclesbiologyChemistry010405 organic chemistrydirect arylationGeneral Chemistry[CHIM.CATA]Chemical Sciences/CatalysisGeneral Medicinebiology.organism_classificationpalladium0104 chemical sciencesC[BOND]H activationTriphosphanesynthetic methodsTetraPalladiumdescription
International audience; Put a ring on it: The use of an air-stable, robust palladium/tridentate phosphane catalyst in direct C[BOND]H and C[BOND]Cl activation reactions is reported (see scheme; DMAc=N,N-dimethylacetamide, TBAB=tetra-n-butylammonium bromide). Electron-rich, electron-poor, and polysubstituted furans (X=O), thiophenes (X=S), pyrroles (X=NR5), and thiazoles were arylated with chloroarenes in the presence of the catalyst.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-08-02 | Angewandte Chemie |