6533b82bfe1ef96bd128def6
RESEARCH PRODUCT
Synthesis of γ-Amino Acid Esters by 1,4-Addition of Deprotonated α-Aminonitriles and α-(Alkylideneamino)nitriles to α,β-Unsaturated Esters.
Ines BergnerTill Opatzsubject
chemistry.chemical_classificationDeprotonationchemistryYield (chemistry)fungiOrganic chemistryGeneral MedicineAmino acidConjugatedescription
α-Aminonitriles and α-(alkylideneamino)nitriles can serve as readily available α-aminocarbanion equivalents. Their conjugate addition to α,β-unsaturated esters followed by reduction furnishes polysubstituted γ-amino acid esters in moderate to high yield.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-07-24 | ChemInform |