6533b82bfe1ef96bd128df16

RESEARCH PRODUCT

CCL27 Signaling in the Tumor Microenvironment

Miguel Martínez-rodríguezCarlos Monteagudo

subject

ChemokineLeukocyte migrationTumor microenvironmentChemokine receptorbiologymedicinebiology.proteinCancer researchCCL27CCR10Atopic dermatitisSkin cancermedicine.disease

description

Chemokines are a group of small proteins which play an important role in leukocyte migration and invasion. They are also involved in the cellular proliferation and migration of tumor cells.Chemokine CCL27 (cutaneous T cell-attracting chemokine, CTACK) is mainly expressed by keratinocytes of the normal epidermis. It is well known that this chemokine plays an important role in several inflammatory diseases of the skin, such as atopic dermatitis, contact dermatitis, and psoriasis. Moreover, several studies have shown an association between CCL27 expression and a variety of neoplasms including skin cancer.In this chapter, we address the role of chemokine CCL27 in the tumor microenvironment in the most relevant cancers of the skin and other anatomical locations. We also make a brief comment on future perspectives and the potential relation of CCL27 with different immunotherapeutic modalities.

yearjournalcountryeditionlanguage
2021-01-01
https://doi.org/10.1007/978-3-030-62658-7_9