6533b82bfe1ef96bd128df8c

RESEARCH PRODUCT

Biological activity of flucycloxuron, a novel benzoylphenylurea derivative, onTenebrio molitor: comparison with diflubenzuron and triflumuron

Jean DelachambreJean-paul DelbecqueS. ChebiraNoureddine Soltani

subject

PharmacologyBenzoylphenylureaCuticlefungiBiological activityCell BiologyBiologyCellular and Molecular Neurosciencechemistry.chemical_compoundDiflubenzuronBiochemistryChitinchemistryEcdysisBotanyProtein biosynthesisMolecular MedicineMolecular BiologyDerivative (chemistry)

description

Flucycloxuron, a novel benzoylphenylurea (BPU) derivative, exhibited insecticidal activity when injected into newly ecdysed pupae ofTenebrio molitor. Mortality occurs because of defective adult ecdysis. Treatment caused a reduction in both cuticle thickness and incorporation of14C-labelled precursor into chitin, although it had no significant effect on the protein synthesis. The potencies of other BPU compounds as inhibitors of chitin biosynthesis have been examined and results showed that diflubenzuron was less effective than either flucycloxuron or triflumuron.

https://doi.org/10.1007/bf01929918