6533b82bfe1ef96bd128dfd7

RESEARCH PRODUCT

Tumor de células de la granulosa extraovárico con mutación FOXL2. Diagnóstico diferencial morfológico e inmunohistoquímico

Raquel Alfonso BallesterDaniel MataErnesto Muñoz SornosaAntonio FerrándezIsidro MachadoCarolina Martínez CiarpagliniGema Nieto Morales

subject

endocrine systemPathologymedicine.medical_specialtyAbdominal painurogenital systemGranulosa cellCD99BiologyPathology and Forensic Medicine03 medical and health sciences0302 clinical medicine030220 oncology & carcinogenesisFemale patientProgesterone receptormedicineImmunohistochemistry030211 gastroenterology & hepatologyDifferential diagnosisCalretininmedicine.symptom

description

Extraovarian granulosa cell tumor is a very uncommon tumor and the identification of a recurrent mutation in FOXL2 may be used as another diagnostic tool along with the classical morphological and immunohistochemical findings. Here, we report a new case of extraovarian granulosa cell tumor in a 57 years old female patient presented with a sub-hepatic mass and abdominal pain. Histopathological examination of the excised mass showed features of adult-type granulosa cell tumor with α-inhibin, calretinin, WT1, S100, CD99 and progesterone receptor immunoreactivity. A FOXL2 mutation was detected on molecular biology study. A final diagnosis was an extraovarian adult-type granulosa cell tumor. We discuss the histopathological and immunohistochemical differential diagnosis.

yearjournalcountryeditionlanguage
2020-04-01Revista Española de Patología
https://doi.org/10.1016/j.patol.2018.07.003