Fatty Acid Profiles in Demented Patients: Identification of Hexacosanoic Acid (C26:0) as a Blood Lipid Biomarker of Dementia

6533b82bfe1ef96bd128e0e4

RESEARCH PRODUCT

Fatty Acid Profiles in Demented Patients: Identification of Hexacosanoic Acid (C26:0) as a Blood Lipid Biomarker of Dementia

Meryam Debbabi Samia Hadj Ahmed Wafa Chaabane Sofiene Ben Ammou Mahbouba Frih Amira Zarrouk Amira Zarrouk Olivier Rouaud Jean-marc Riedinger Gérard Lizard Mohamed Hammami Sonia Hammami

subject

Male medicine.medical_specialty Pathology Chromatography Gas Erythrocytes Blood lipids Neuropsychological Tests Biology Mass Spectrometry chemistry.chemical_compound Internal medicine medicine Humans Dementia Vascular dementia Aged Aged 80 and over chemistry.chemical_classification Fatty acid metabolism General Neuroscience Fatty Acids Fatty acid Lipid metabolism General Medicine Middle Aged Peroxisome medicine.disease Psychiatry and Mental health Clinical Psychology Endocrinology ROC Curve chemistry Biomarker (medicine)Dementia Female Geriatrics and Gerontology Mental Status Schedule

description

Background: Several lipid metabolism alterations have been described in the brain and plasma of Alzheimer’s disease (AD) patients, suggesting a relation between lipid metabolism alteration and dementia. 15 16 Objective: We attempted to identify blood fatty acids as biomarkers of dementia. 17 Methods: Fatty acid profiles were established using gas chromatography with or without mass spectrometry on matched plasma and red blood cells (RBCs) of demented patients diagnosed with AD, vascular dementia, or other dementia, and compared with a control group of elderly individuals. The severity of dementia was evaluated with the Mini-Mental State Examination test. 18 19 20 Results: Fatty acid analysis showed significant variations of fatty acid levels in demented patients including AD patients. The highest plasma and RBC accumulation was found with hexacosanoic acid (C26:0). These data suggest that alterations of desaturase and elongase activity may contribute to cognitive dysfunction. 21 22 23 Conclusion: The variations of fatty acid levels and the accumulation of C26:0 in the plasma and RBCs highlight an alteration of fatty acid metabolism in demented patients and point toward possible peroxisomal dysfunction. It is suggested that C26:0 may constitute a convenient blood biomarker of dementia that could be useful in routine medical practice. 24 25 26

year	journal	country	edition	language
2014-11-28	Journal of Alzheimer's Disease

https://doi.org/10.3233/jad-142046