6533b82bfe1ef96bd128e18b
RESEARCH PRODUCT
Expressional downregulation of neuronal-type NO synthase I in guinea pig skeletal muscle in response to bacterial lipopolysaccharide
Ute Gödtel-armbrustUlrich FörstermannIngolf Gathsubject
LipopolysaccharidesMaleLipopolysaccharideGuinea PigsBiophysicsDown-RegulationAnti-NO synthase antibodiesBiochemistryNitric oxideGuinea pigchemistry.chemical_compoundDownregulation and upregulationStructural BiologyChapsGeneticsmedicineAnimalsNO synthase mRNAMuscle SkeletalMolecular BiologyNO synthase activityNeuronsMessenger RNAbiologySkeletal muscleCell BiologyMolecular biologyNitric oxide synthasemedicine.anatomical_structurechemistrybiology.proteinNitric Oxide SynthaseNG-nitro-l-argininedescription
AbstractWe have investigated the expression of neuronal-type NO synthase I (NOS I) and inducible-type NOS II in guinea pig skeletal muscle (diaphragm). Expression of NOS I mRNA and protein was highest in muscle of specific pathogen-free animals, lower in normally bred animals, and lowest in lipopolysaccharide (LPS)-treated animals. NOS II mRNA and protein levels were highest in muscle of LPS-treated animals. Elevated NOS activity in muscle from LPS-treated animals was less susceptible to the NOS I-selective inhibitor NG-nitro-l-arginine. Expressional downregulation of NOS I in sepsis may have implications for contractile function of skeletal muscle.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-06-30 | FEBS Letters |