6533b82bfe1ef96bd128e1f0
RESEARCH PRODUCT
TTF-1/p63-Positive Poorly Differentiated NSCLC: A Histogenetic Hypothesis from the Basal Reserve Cell of the Terminal Respiratory Unit
Ada Maria FlorenaDaniela CabibiCalogero CipollaAnna MartoranaSandro BellaviaVito RodolicoNadia BarracoMassimo CajozzoAntonino Giulio Giannonesubject
0301 basic medicinePathologymedicine.medical_specialtyendocrine systemAlveolar EpitheliumClinical Biochemistryhistogenetic hypothesisBiologyNSCLCArticle03 medical and health sciencesBasal (phylogenetics)0302 clinical medicineterminal respiratory unitmedicineCarcinomabasal reserve cellslcsh:R5-920p63LungBasal reserve cellCancerrespiratory systemmedicine.disease030104 developmental biologymedicine.anatomical_structurenon-small-cell lung cancerTTF-1030220 oncology & carcinogenesisAdenocarcinomaImmunohistochemistrylcsh:Medicine (General)ImmunostainingHistogenetic hypothesidescription
TTF-1 is expressed in the alveolar epithelium and in the basal cells of distal terminal bronchioles. It is considered the most sensitive and specific marker to define the adenocarcinoma arising from the terminal respiratory unit (TRU). TTF-1, CK7, CK5/6, p63 and p40 are useful for typifying the majority of non-small-cell lung cancers, with TTF and CK7 being typically expressed in adenocarcinomas and the latter three being expressed in squamous cell carcinoma. As tumors with coexpression of both TTF-1 and p63 in the same cells are rare, we describe different cases that coexpress them, suggesting a histogenetic hypothesis of their origin. We report 10 cases of poorly differentiated non-small-cell lung carcinoma (PD-NSCLC). Immunohistochemistry was performed by using TTF-1, p63, p40 (&Delta
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-06 | Diagnostics |